Danish Study Shows Pfizer & Moderna Negative Effectiveness After 3 Months Against Omicron

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Vaccine effectiveness against SARS-CoV-2 infection with the Omicron or Delta variants following a two-dose or booster BNT162b2 or mRNA-1273 vaccination series: A Danish cohort study

Study shows that after three months the vaccine effectiveness of Pfizer & Moderna against Omicron is actually negative. Pfizer customers are 76.5% more likely and Moderna customers are 39.3% more likely to be infected than unvaxxed people.

The study is showing original research results with early estimates from Danish nationwide databases of vaccine effectiveness (VE) against the novel SARS-CoV-2 Omicron variant (B.1.1.529) up to five months after a primary vaccination series with the BNT162b2 or mRNA-1273 vaccines.

The study provides evidence of protection against infection with the Omicron variant after completion of a primary vaccination series with the BNT162b2 or mRNA-1273 vaccines; in particular, we found a VE against the Omicron variant of 55.2% (95% confidence interval (CI): 23.5 to 73.7%) and 36.7% (95% CI: 69.9 to 76.4%) for the BNT162b2 and mRNA-1273 vaccines, respectively, in the first month after primary vaccination. However, the VE is significantly lower than that against Delta infection and declines rapidly over just a few months. The VE is re-established upon revaccination with the BNT162b2 vaccine (54.6%, 95% CI: 30.4 to 70.4%).

The authors have declared no competing interest and the study did not receive any funding.


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  1. Adam

    December 25, 2021 at 8:26 am

    South Africa has scrapped self-isolation for people who test positive for Covid but are asymptomatic. Quarantine for contacts, both vaccinated and unvaccinated, has also been removed following the spread of the Omicron variant.

  2. Jordan

    December 25, 2021 at 8:32 am

    Seems like we are somewhere between the anger and bargaining stages of mRNA remorse.

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