Published Study: https://pmc.ncbi.nlm.nih.gov/articles/PMC7505114/
Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells. This may be related to the regulation of multiple signaling pathways by ivermectin through PAK1 kinase. On the other hand, ivermectin promotes programmed cancer cell death, including apoptosis, autophagy and pyroptosis. Ivermectin induces apoptosis and autophagy is mutually regulated. Interestingly, ivermectin can also inhibit tumor stem cells and reverse multidrug resistance and exerts the optimal effect when used in combination with other chemotherapy drugs.
Mechanisms of action
IVM induces different programmed cell death patterns in different tumor cells, the main form of IVM induced programmed cell death is apoptosis.
- Apoptosis
- Programmed cell death
- Autophagy
- Lysosomal-dependent form of programmed cell death.
- Pyroptosis
- Inflammatory cell death induced by inflammasomes
Kathleen T Ruddy, MD
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