Boosters Provided A Small Benefit.
Current Covid-19 vaccines cannot deliver equivalent protection to all individuals. FUture approaches should aim to improve vaccine immunogenicity and involve a range of novel strategies, including variant-specific immunogenic agents, introduction proteins in addition to spike, and the incorporation of immunodominant cellular epitopes. However, these approaches are unlikely to overcome immune suppression in the most vulnerable groups and for that reason additional approaches, such as administration of anti-spike monoclonal antinodes and antivirals, should also be considered.
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