Cardiovascular Effects of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents
Study focuses on cardiovascular effects, particularly myocarditis and pericarditis events, after BNT162b2 mRNA COVID-19 vaccine injection, in Thai adolescents, 13 to 18, both sexes.
This prospective cohort study, students from two schools aged 13–18 years, who received the second dose of the BNT162b2 vaccine.
All healthy and without any abnormal symptoms before receiving the second dose of vaccine.
Collected at baseline, Day 3, Day 7, and Day 14
N = 314
Analysis, n = 301
Found in 29.24% of patients,
ranging from tachycardia, palpitation, and myopericarditis.
Most common cardiovascular effects
Shortness of breath, 6.64%
Chest pain, 4.32%
Abnormal ECG finding, 54 patients (17.94%)
Seven participants (2.33%)
At least one elevated cardiac biomarker or positive lab assessments
Confirmed in one patient after vaccination.
Two patients had suspected pericarditis
Four patients had suspected subclinical myocarditis
Three patients had minimal pericardial effusion
Myocarditis and Sudden Cardiac Death in the Young
Myocarditis accounts for up to 20% of sudden cardiac deaths in young adults.
During the follow-up period, (14 days)
After receiving the second dose of vaccine,
two patients were hospitalized,
one patient was supervised in the ICU during hospitalization,
(mainly for observation of arrhythmia).
The clinical presentation of myopericarditis after vaccination was usually mild, with all cases fully recovering within 14 days.
Hence, adolescents receiving mRNA vaccines should be monitored for side effects.
Clinical Trial Registration: NCT05288231
Incidence, risk factors, natural history, and hypothesised mechanisms of myocarditis and pericarditis following covid-19 vaccination: living evidence syntheses and review
Male adolescents and male young adults are at the highest risk of myocarditis after an mRNA vaccination.
Vaccines for COVID-19
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COVID-19 Vaccines for Children and Teens
CDC recommends covid -19 vaccines for everyone 6 months and older and boosters for everyone 5 years and older,